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. Author manuscript; available in PMC: 2019 Sep 1.
Published in final edited form as: J Comp Neurol. 2018 Aug 22;526(13):2048–2067. doi: 10.1002/cne.24478

Figure 13. Model of the regionalized role of AVP in SCN period and phase computation.

Figure 13

Schematic representation of the SCN network in the sagittal plane, with the location of the shell and core compartments illustrated and subdivided into anterior, middle, and posterior regions. Avp is rhythmically expressed throughout the SCN in wild type mice, but higher basal Avp expression and other region-specific patterns of gene expression for signaling transcripts are indicated where appropriate. Arrows below illustrate putative effects of AVP and VIP signaling on period and phase. Question marks alongside symbols for VIP signaling reflect the speculative nature of region-specific effects because it is unknown how VIP deficiency affects clock function across the anteroposterior SCN.