Table 4:
HIV-infected young MSM and transwomen in Atlanta, GA 2009–2016, Association between anal histology and demographic, behavioral and clinical factors
| Characteristics, N (%) | hHSIL, N=42 (a) | hLSIL, N=20 (b) | Negative, N=10 (c) |
Omnibus P-value |
Pairwise Comparisons |
| Demographics | |||||
| Race | |||||
| African American | 38 (91%) | 20 (100%) | 9 (90%) | 0.403 | |
| Other | 4 (10%) | 0 (0%) | 1 (10%) | ||
| Gender of sex partners | |||||
| Men only | 33 (79%) | 17 (85%) | 6 (60%) | 0.340 | |
| Men and women | 9 (21%) | 3 (15%) | 4 (40%) | ||
| Education | |||||
| High School or Less | 19 (45%) | 13 (65%) | 5 (50%) | 0.345 | |
| College | 23 (55%) | 7 (35%) | 5 (50%) | ||
| Behavioral | |||||
| Age at coitarche, mean (SD) | 14.8 (3.5) | 14.2 (2.7) | 13.1 (4.6) | 0.587 | |
| Intercourse | |||||
| Both + Receptive Only | 42 (100%) | 20 (100%) | 10 (100%) | NA | |
| Insertive Only | 0 (0%) | 0 (0%) | 0 (0%) | ||
| Number of Partners | |||||
| 1 to 5 | 6 (17%) | 5 (31%) | 1 (10%) | 0.017* | a ≠ c, b ≠ c |
| 6 to 10 | 7 (20%) | 3 (19%) | 7 (70%) | ||
| 11 to 20 | 7 (20%) | 1 (6%) | 2 (20%) | ||
| 21 or more | 15 (43%) | 7 (44%) | 0 (0%) | ||
| Abuse, n=54 | |||||
| Yes | 14 (40%) | 2 (20%) | 6 (67%) | 0.144 | |
| No | 21 (60%) | 8 (80%) | 3 (33%) | ||
| Transactional Sex, n=34 | |||||
| Yes | 8 (38%) | 1 (11%) | 0 (0%) | 0.171 | |
| No | 13 (62%) | 8 (89%) | 4 (100%) | ||
| Tobacco Use | 14 (33%) | 7 (35%) | 5 (50%) | 0.610 | |
| Marijuana Use | 23 (55%) | 10 (50%) | 6 (60%) | 0.868 | |
| Marijuana and alcohol use | 21 (50%) | 7 (35%) | 6 (60%) | 0.371 | |
| History of rectal STIs | 23 (55%) | 10 (56%) | 7 (77%) | 0.434 | |
| Characteristics, N (%) | hHSIL, N=42 (a) | hLSIL, N=20 (b) | Negative, N=10 (c) |
Omnibus P-value |
|
| Clinical | |||||
| Age at histology, mean (SD) | 22.0 (1.9) | 21.9 (2.7) | 22.5 (1.9) | 0.718 | |
| CD4 Countsa | |||||
| At baselineb, mean (95% CI) | 213 (152 – 284) | 307 (193 – 447) | 251 (47 – 617) | 0.389 | |
| At biopsy, mean (95% CI) | 391 (338 – 447) | 417 (322 – 524) | 378 (193 – 626) | 0.874 | |
| Viral Loads | |||||
| At baseline, median (IQR) | 27,790 (7,150 – 68,980) |
50,710 (21,480 – 131,893) |
31,015 (1,630 – 258,180) |
0.478 | |
| At biopsy, median (IQR) | 40 (40 – 480) | 40 (40 – 40) | 145 (40 – 2,415) | 0.484 | |
| At biopsy # UDc (%) | 27 (66%) | 15 (79%) | 4 (50%) | 0.316 | |
| Number of HPV vaccines | |||||
| 0 | 40 (95%) | 16 (80%) | 10 (100%) | 0.092 | |
| 1 or more | 2 (5%) | 4 (20%) | 0 (0%) | ||
| Anal Warts (external or internal) | |||||
| Yes | 36 (86%) | 16 (80%) | 8 (80%) | 0.737 | |
| No | 6 (14%) | 4 (20%) | 2 (20%) | ||
a
CD4s regression modeled as square root of CD4, presented squared for interpretation purposes
b
Baseline indicates at the time of HIV diagnosis
c
UD: Undetectable