Trabecular bone volume is decreased in GATA4 OCN-cKO mice. (A, B) μCT reconstruction of trabecular bone in the distal tibia metaphysis of 14-week-old female mice. (C) Mean percentage bone volume (BV/TV), (D) trabecular number (Tb.N), (E) trabecular separation (Tb.Sp), (F) trabecular thickness (Tb.Th), (G) cortical thickness and (H) cortical porosity of WT and OCN-cKO mice. Black bars indicate wildtype (WT) mice; white bars indicate GATA4 OCN-cKO mice. Data are mean ± standard deviation from 12 WT and 12 cKO mice. Student’s t-test: *P < 0.05; **P < 0.01 compared with WT.