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. Author manuscript; available in PMC: 2019 Mar 17.
Published in final edited form as: Nat Immunol. 2018 Sep 17;19(10):1137–1145. doi: 10.1038/s41590-018-0208-x

Figure 6.

Figure 6

The role of alternative polyadenylation in cellular context dependent regulation of gene expression by miR-155. (a) A heatmap showing the usage changes in multi-isoform 3′UTRs across all four cell-types. The usage index (UI) represents the percentage of the shorter isoform usage for two-isoform 3′UTRs, while for 3′UTRs with more isoforms it represents the usage of the short isoform with the most significant usage change. “Elongation” corresponds to the genes with significantly higher usage of longer isoforms in one cell type compared to the rest, whereas “shortening” corresponds to the genes with significantly higher usage of shorter isoforms in one cell type compared to the rest. (b) Number of 3′UTRs containing miR-155 targets and displaying cell type specific ApA differences. (c) iCLIP, RNA-Seq and PolyA-Seq read coverage tracks in dendritic cell and CD4+ T cell for Rbm33. (d) Venn diagram showing the number of shared and cell-specific miR-155 target genes in dendritic cell and B cell, before and after removing genes with cell type specific ApA differences. The data are representative of four independent PolyA-Seq experiments.