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. 2018 Jun 20;16:126–138. doi: 10.1016/j.molmet.2018.06.012

Figure 2.

Figure 2

In vivo insulin sensitivity analysis from Cvs and three months post Cvs mice. Blood glucose levels before and during the hyperinsulinemic-euglycemic clamp (A, D) n = 10–11, endogenous glucose production (EGP) and glucose infusion rate (GIR) under basal conditions (B, E) n = 9–11, as well as insulin-mediated suppression of EGP and stimulation of glucose disposal (Rd) (C, F) in mice post Cvs (A–C) and three months post Cvs (Cvs3m) (D–F) compared to the age-matched controls (Ctrl and Ctrl3m, respectively) n = 9–11. Blood biochemical parameter after bolus injection of insulin to Cvs3m and Cvs3m mice; plasma blood glucose (G), plasma NEFA (H) and plasma triglyceride (I) n = 6. Data presented as means ± s.e.m. Statistical analyses were done by two-tailed unpaired Student's t-test (A–F) or by Two-Way ANOVA followed by Bonferroni post hoc (G–I). *p < 0.05, **p < 0.01, ***p < 0.001.