Translational association of chronic variable stress with FGF21. Interaction between FGF21 serum levels and cortisol morning serum levels (A–C) as well as self-reported stress (D–F) and coping (G–I) as a marker for resilience in medical students during semester break (A, D and G), end of semester exam period (B, E and H) and 10–12 weeks after successful exams (C, F and I). A, n = 19; B and C, n = 38. Results of linear regression analysis are shown.