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Outline of the study design and setup for investigating the interaction of P. gingivalis with hDFSCs and the resulting effects on neutrophils in a newly established triple-culture system. a Direct interaction of neutrophils and stem cells. b Direct interaction of living P. gingivalis and hDFSCs (Box I) is required for downstream effects on neutrophils (Box II). The question is, which factors in Box I are essential to modify the interaction in Box II?
