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. 2018 Jul 26;16:55–64. doi: 10.1016/j.molmet.2018.07.009

Figure 1.

Figure 1

Relationship between VSG surgery improvement of adiposity and glucose tolerance with changes in plasma LPC and TMAO levels and gut microbiota in C57BL/6 mice. (A,B) Body weight and adiposity, measured as % body fat, in HFHC-fed mice without surgery (N = 6) or with sham (N = 6) or VSG procedures (N = 8). (C) Blood glucose levels in response to a bolus lipid-glucose meal in HFHC-fed mice without surgery (N = 6) or with sham (N = 6) or VSG procedures (N = 8). (D) Area under the curve analysis of the glucose tolerance test data reported in C. (E) Distribution of major bacterial phyla in the cecum of chow- or HFHC-fed mice without surgery (N = 6) or with sham (N = 6) or VSG procedures (N = 7). (F) Plasma LPC levels in HFHC-fed mice without surgery (N = 6) or with sham (N = 6) or VSG procedures (N = 8). (G) Plasma TMAO levels in control (N = 5), sham- (N = 5) and VSG-operated (N = 8) mice that were fed the HFHC diet for 8 weeks. (H) Expression levels of LPCAT3 in ileal intestine of control (N = 3), sham- (N = 3), and VSG-operated (N = 5) mice. Data are presented as mean ± s.e.m. *P < 0.01 and #P < 0.05 indicate differences from control group and the sham-operated group by one way ANOVA (A,B,C,E,G, H) or Mann–Whitney rank sum test (D and F). γ indicates differences from chow-fed mice at P < 0.05.