Table 3. Multivariate analysis of the DFS and OS in invasive breast carcinomas.
| Characteristic | DFS | p-value | OS | p-value | ||
|---|---|---|---|---|---|---|
| HR | 95% CI | HR | 95% CI | |||
| ER (positive vs. negative) | 0.876 | 0.453–1.694 | 0.694 | 2.022 | 0.918–4.455 | 0.081 |
| PR (positive vs. negative) | 1.031 | 0.561–1.892 | 0.922 | 0.540 | 0.257–1.134 | 0.103 |
| Ki-67 (< 14% vs. ≥ 14%) | 1.354 | 0.787–2.328 | 0.274 | 2.689 | 1.338–5.403 | 0.005 |
| Histologic grade (grade 1 vs. grade 2, 3) | 1.354 | 0.795–2.307 | 0.264 | 1.328 | 0.727–2.425 | 0.356 |
| T stage ( ≤ 5 cm vs. > 5 cm) | 1.606 | 1.061–2.431 | 0.025 | 1.349 | 0.830–2.195 | 0.227 |
| N stage (N0 vs. N1–3) | 1.732 | 1.406–2.134 | < 0.001 | 1.845 | 1.441–2.362 | < 0.001 |
| RBM3 (> 4 vs. ≤ 4) | 0.199 | 0.114–0.346 | < 0.001 | 0.245 | 0.133–0.451 | < 0.001 |
DFS=disease-free survival; OS=overall survival; HR=hazard ratio; CI=confidence interval; ER=estrogen receptor; PR=progesterone receptor; RBM3=RNA-binding motif protein 3.