Figure 3. Effects of hypoxia-inducible factor 1α (HIF-1α) and SMAD family member 3 (SMAD3) on cell proliferation and apoptosis of breast cancer cells. (A, B) Cell proliferation of different cell lines was influenced with different treatment. (C, D) Cell apoptosis of different cell lines was influenced with different treatment.

SIS3=SMAD3 inhibitor; C=control; NC=negative control; over=overexpression. ^*p<0.05.