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. 2018 Sep 20;21(3):259–266. doi: 10.4048/jbc.2018.21.e42

Figure 4. Hypoxia-inducible factor 1α (HIF-1α) is a positive upstream regulator of transforming growth factor β1 (TGF-β1)/SMAD family member 3 (SMAD3) pathway in breast cancer. (A, B) HIF-1α overexpression significantly increased the expression levels of TGF-β 1 and SMAD3 in BT-483 and MCF-7 cell line. (C, D) SMAD3 overexpression showed no significant effects on the expression of HIF-1α or TGF-β 1 in BT-483 and MCF-7 cell line.

Figure 4

C=control; NC=negative control; over=overexpression; GAPDH=glyceraldehyde-3-phosphate dehydrogenase. *p<0.05.