Figure 6. Overexpression of hypoxia-inducible factor 1α (HIF-1α) and the growth of transplanted tumor in mice. (A) Representative tumors collected at 6 week after injection was shown. (B) Tumors were derived from MCF-7 cells (control), MCF-7 cells transfected with empty vector (negative control), and HIF-1α-overexpressing MCF-7 cell lines (overexpression), and the tumor growth rate was recorded and compared. (C) Comparison of tumor weight at week 6 between tumors derived from MCF-7 cells (control), MCF-7 cells transfected with empty vector (negative control), and HIF-1α-overexpressing MCF-7 cell line (overexpression).

C=control; NC=negative control; over=overexpression. ^*p<0.05.