Fig. 4.

Comparison of expected versus observed regression results. Quantile–quantile plot of expected versus observed P-values of composite network structure and network composition metrics in relation to neurological function and disability in the full cohort (a, b) and subgroups of asymptomatic (c, d) and MS participants (e, f). The expected P-values (-log10[P-value]) are shown on the x-axis and the observed P-values (-log10[P-value]) are shown on the y-axis. The dark gray area indicate the confidence interval ranges as generated by chance at a threshold of P = 0.10 and the light gray is for P = 0.05. The observed values for composition, and not structure, are outside of the gray areas, suggesting that composition is associated with the MSRS-R score beyond chance after accounting for multiple testing burden and correlation structure of the composition variables