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. 2018 Sep 26;9:3943. doi: 10.1038/s41467-018-06336-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Three modes of SV release during an AP train. Monte Carlo simulations were used to trace back each released SV to its status immediately before the last AP preceding release. The simulations used a modified 2-step model incorporating inhibition of release linked to previous synapse history (Supplementary Fig. 6). a Having sorted out each release SV according to its status just before the AP preceding release, the total histogram of release latencies (dashed line) was decomposed into release from docking site (red), release from replacement site (blue; note slower time course of this component) and release from recycling pool (yellow). b Cumulated plots from a. c Monoexponential fits of the red and blue components in b yield time constants τ_DS (red) and τ_RS (blue). Dotted lines indicate the values of τ_fast and τ_slow for comparison. This suggests that τ_fast and τ_slow correspond to the release of SVs coming, respectively, from docking sites and from replacement sites. In addition, the two-fold increase both in τ_DS and τ_RS indicates an increasing participation of slowed release due to previous release activity. d Occupancy of replacement site (ρ) and docking site (δ) during an AP-train