Table 1.
Genome-wide significant results from the meta-analyses of lateral ventricular volume
| SNP | Chr | Annotation | Gene(s) | A1/A2 | Stage 1 | Stage 2 | Stage 3 combined | |||
|---|---|---|---|---|---|---|---|---|---|---|
| Zscore | P | Zscore | P | Zscore | P | |||||
| rs34113929a | 3q28 | intergenic | SNAR-I,OSTN | A/G | −6.84 | 7.70E−12 | −5.05 | 4.44E−07 | −8.27 | 1.37E−16 |
| rs9937293a | 16q24.2 | intergenic | FOXL1,C16orf95 | A/G | 5.65 | 1.63E−08 | 5.61 | 2.03E−08 | 7.84 | 4.45E−15 |
| 7:2760334:C_CTa | 7p22.3 | intergenic | AMZ1,GNA12 | D/I | −5.88 | 4.21E−09 | −4.48 | 7.34E−06 | −7.21 | 5.61E−13 |
| rs12146713 | 12q23.3 | intronic | NUAK1 | T/C | −5.01 | 5.57E−07 | −5.44 | 5.32E−08 | −7.28 | 3.25E−13 |
| rs4820299 | 22q13.1 | intronic | TRIOBP | T/C | −4.79 | 1.71E−06 | -4.49 | 7.04E−06 | −6.46 | 1.05E−10 |
| rs35587371 | 10p12.31 | intronic | MLLT10 | A/T | −4.89 | 1.03E−06 | −3.32 | 9.12E−04 | −5.61 | 2.07E−08 |
| rs7936534 | 11q23.1 | intergenic | ARHGAP20,C11orf53 | A/G | 4.25 | 2.12E−05 | 3.71 | 2.04E−04 | 5.54 | 2.96E−08 |
Variant that showed the lowest p-value in the fixed effect sample-size weighted Z-score meta-analysis for each locus is shown
SNP: single-nucleotide polymorphism, Chr: chromosome, A1/A2: effect allele/other allele, Freq: frequency of effect allele, Zscore: Z score from METAL, P: p-value
aVariants that surpassed genome-wide significance threshold in stage 1 meta-analysis; remaining SNPs listed in the table reached genome-wide significance threshold in combined, stage 3, meta-analysis