Table 2.
The results of genetic correlation between the lateral ventricular volume and anthropometric traits, brain volumes, neurological and psychiatric diseases and personality traits
Category | Phenotype | PMID | N | rg | SE | P |
---|---|---|---|---|---|---|
Anthropometric | ||||||
Height | 20881960 | 133,859 | −0.135 | 0.049 | 5.70E−03 | |
Infant head circumference | 22504419 | 10,768 | 0.284 | 0.108 | 8.70E−03 | |
Child birth length | 25281659 | 28,459 | −0.133 | 0.089 | 1.34E−01 | |
Child birth weight | 23202124 | 26,836 | −0.118 | 0.102 | 2.47E−01 | |
Brain volume | ||||||
Mean thalamus | 25607358 | 13,193 | −0.591 | 0.127 | 3.14E−06 | |
Mean pallidum | 25607358 | 13,142 | −0.29 | 0.129 | 2.47E−02 | |
ICV | 25607358 | 11,373 | 0.347 | 0.133 | 9.00E−03 | |
Mean accumbens | 25607358 | 13,112 | −0.29 | 0.158 | 6.64E−02 | |
Mean putamen | 25607358 | 13,145 | −0.15 | 0.089 | 9.13E−02 | |
Mean hippocampus | 25607358 | 13,163 | −0.204 | 0.132 | 1.20E−01 | |
Mean caudate | 25607358 | 13,171 | 0.012 | 0.105 | 9.06E−01 | |
Neurological diseases | ||||||
Alzheimer’s disease | 24162737 | 54,162 | 0.181 | 0.11 | 9.87E−02 | |
Parkinson’s disease | 19915575 | 5691 | −0.096 | 0.084 | 2.55E−01 | |
Amyotrophic lateral sclerosis | 27455348 | 36,052 | −0.032 | 0.128 | 8.04E−01 | |
White matter hyperintensities | 25663218 | 17,940 | 0.100 | 0.094 | 2.87E−01 | |
Personality traits | ||||||
Neo-conscientiousness | 21173776 | 17,375 | −0.359 | 0.158 | 2.27E−02 | |
Neo-openness to experience | 21173776 | 17,375 | 0.088 | 0.118 | 4.56E−01 | |
Neuroticism | 27089181 | 170,911 | −0.03 | 0.065 | 6.45E−01 | |
Psychiatric traits | ||||||
ADHD | 20732625 | 5422 | −0.276 | 0.152 | 6.90E−02 | |
PGC cross-disorder analysis | 23453885 | 61,220 | −0.121 | 0.071 | 8.65E−02 | |
Major depressive disorder | 22472876 | 18,759 | −0.165 | 0.102 | 1.05E−01 | |
Schizophrenia | 25056061 | 77,096 | −0.067 | 0.044 | 1.30E−01 | |
Subjective well-being | 27089181 | 298,420 | 0.087 | 0.075 | 2.50E−01 | |
ADHD (no GC) | 27663945 | 17,666 | −0.151 | 0.149 | 3.11E−01 | |
Depressive symptoms | 27089181 | 161,460 | −0.038 | 0.071 | 5.93E−01 | |
Autism spectrum disorder | 0 | 10,263 | 0.041 | 0.092 | 6.53E−01 | |
Anorexia nervosa | 24514567 | 17,767 | 0.011 | 0.056 | 8.43E−01 | |
Bipolar disorder | 21926972 | 16,731 | 0.009 | 0.078 | 9.12E−01 |
rg: genetic correlation, SE: standard error, P: p-value