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. 2018 Sep 26;8:14373. doi: 10.1038/s41598-018-32393-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Genomic and functional context of significant CpG site regulators of genes encoding miRNAs which are differentially methylated in BCVY-metEPICVal samples. Percentage of methylation differences for statistically significant CpG sites from BCVY-BCO comparison according to location of the CpG relative to the island (A) and to the UCSC gene region feature category and regulatory elements (B). Red bars represent hypermethylation in BCVY and green bars represents hypomethylation. *Statistically significant p-values (p < 0.001). N/S: north/south; upstream or downstream to the CpG island.