Table 1.
Comparison of infarct volume and CBF based on ADC and ASL in two groups.
| Control (n = 10 for 1 h and 7 for 4 h) | Dehydration (n = 8) | p-value | |
|---|---|---|---|
| Volume of infarction (mm3) | |||
| 1 h after MCAO | 39.4 (15.3) | 59.9 (46.2) | 0.573 |
| 4 h after MCAO | 75.9 (22.2) | 105.5 (46.3) | 0.040* |
| Ratio of progression | 1.46 | 2.34 | 0.121 |
| Absolute volume of progression | 24.1(9.4) | 45.6 (36.8) | 0.021* |
| ADC value (× 10−6 mm2/sec) | |||
| Infarct side | |||
| 1 h after MCAO | 456.1 (53.6) | 441.6 (54.9) | 0.573 |
| 4 h after MCAO | 525.5 (75.0) | 449.5 (46.3) | 0.867 |
| Normal side | |||
| 1 h after MCAO | 829.2 (45.6) | 789.4 (40.8) | 0.122 |
| 4 h after MCAO | 851.5 (41.3) | 816.0 (44.4) | 0.694 |
| Ratio (Infarct/Normal) | |||
| 1 h after MCAO | 0.55 | 0.56 | 0.573 |
| 4 h after MCAO | 0.61 | 0.55 | 0.955 |
| Relative CBF (ml/100 g−1min−1) | |||
| Infarct side | |||
| 1 h after MCAO | 10.6 (5.2) | 5.7 (2.6) | 0.101 |
| 4 h after MCAO | 10.9 (5.6) | 7.7 (3.1) | 0.397 |
| Normal side | |||
| 1 h after MCAO | 25.6 (5.5) | 19.8 (4.8) | 0.027* |
| 4 h after MCAO | 24.1 (2.8) | 20.7 (2.9) | 0.040* |
| Ratio (Infarct/Normal) | |||
| 1 h after MCAO | 0.42 | 0.30 | 0.408 |
| 4 h after MCAO | 0.44 | 0.37 | 0.613 |
| Recovery of perfusion in 4 h | |||
| Absolute value of infarct side | 1.1 (3.4) | 2.0 (2.6) | 0.189 |
| Absolute value of normal side | −0.1 (4.8) | 0.9 (4.4) | 0.121 |
| Ratio (4 h/1 h of infarct side) | 1.1 (0.3) | 1.6 (1.1) | 0.054 |
| Ratio (Infarct/Normal) | 1.1 (0.5) | 1.6 (1.3) | 0.336 |
*
p < 0.05.