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. 2018 Sep 20;12:641. doi: 10.3389/fnins.2018.00641

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Copyright © 2018 Overall and Kempermann.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Scale freedom of the hippocampal transcriptome network. The number of neighbors of each node (k) and the probability of nodes having k neighbors (p) are plotted for the correlation thresholds 0.1–0.9. The log-log plots of these values reveal a linear relationship when a network exhibits “scale free” behavior. Scale freedom is a property seen in most biological networks. Because the true biological network underlying a correlation network is expected to exhibit this behavior, a threshold where a linear relationship is first seen could indicate an appropriate threshold selection.