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. 2018 Sep 20;12:644. doi: 10.3389/fnins.2018.00644

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Copyright © 2018 Zhang, Wang and He.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Glycine-histidine-lysine (GHK) alleviates hemin-induced apoptosis of SH-SY5Y cells. (A,B) Bax and Bcl-2 expression in GHK-treated SH-SY5Y cells. GHK treatment decreases the rate of Bax/Bcl-2 expression following hemin treatment. (C) GHK treatment increases the survival of SH-SY5Y cells following hemin-induced injury in a concentration-dependent manner. (D) GHK treatment decreases LDH release in a concentration-dependent manner. (Data are represented as the mean ± SD, n = 3, and ^∗p < 0.05.)