Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Sep 20;12:644. doi: 10.3389/fnins.2018.00644

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2018 Zhang, Wang and He.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Vascular endothelial growth factor A (VEGFA), the functional target gene of miR-339-5p. (A). To determine the mechanism via which miR-339-5p acts on SH-SY5Y cells, we predicted the possible target genes of miR-339-5p. The results were examined in conjunction with the effects of GHK treatment to identify intersectional effects on neuronal gene expression for three genes. (B,C) Levels of mRNA and protein expression for general transcription factor II-I (GTF2I), membrane-associated guanylate kinase (MAGI2), and VEGFA in GHK-treated SH-SY5Y cells, compared with control values. (D) Binding sites for miR-339-5p and VEGFA. (E) Levels of luciferase activity in SH-SY5Y cells co-transfected with miR-339-5p and VEGFA. (Data are represented as the mean ± SD, n = 3 and ^∗p < 0.05.)