Table 3.
Top GSEA enriched gene-sets in livers of 10 months old mice exposed pre- or neonatally to BDE-47.
| Gene set | Prenatal exposure | Neonatal exposure | ||||
|---|---|---|---|---|---|---|
| NES | NOM p-val | FDR q-val | NES | NOM p-val | FDR q-val | |
| HALLMARK COLLECTION OF GENE-SETS | ||||||
| Unfolded protein response | −2.06 | 0.000 | 0.003 | −1.98 | 0.000 | 0.003 |
| MYC targets V2 | −2.04 | 0.000 | 0.002 | −1.81 | 0.006 | 0.017 |
| MYC targets V1 | −2.01 | 0.000 | 0.002 | −2.00 | 0.000 | 0.004 |
| DNA repair | −1.93 | 0.000 | 0.006 | −1.62 | 0.011 | 0.054 |
| Cholesterol homeostasis | −1.66 | 0.010 | 0.060 | −1.80 | 0.008 | 0.018 |
| MTORC1 signaling | −1.61 | 0.005 | 0.074 | −1.64 | 0.004 | 0.052 |
| Interferon gamma response | −1.39 | 0.050 | 0.234 | −2.04 | 0.000 | 0.006 |
| Interferon alpha response | −1.38 | 0.086 | 0.205 | −1.84 | 0.001 | 0.016 |
| Protein secretion | −1.22 | 0.181 | 0.365 | −1.65 | 0.007 | 0.052 |
| Bile acid metabolism | 1.62 | 0.020 | 0.409 | 2.16 | 0.000 | 0.056 |
| KEGG COLLECTION OF GENE-SETS | ||||||
| Ribosome | −2.49 | 0.000 | 0.000 | −1.59 | 0.019 | 0.266 |
| Spliceosome | −1.92 | 0.000 | 0.087 | −1.86 | 0.000 | 0.187 |
| RNA polymerase | −1.90 | 0.007 | 0.097 | −1.48 | 0.072 | 0.302 |
| Protein export | −1.85 | 0.014 | 0.107 | −2.04 | 0.002 | 0.085 |
| REACTOME COLLECTION OF GENE-SETS | ||||||
| Translation | −2.62 | 0.000 | 0.000 | −1.87 | 0.000 | 0.187 |
| SRP dependent cotranslational protein targeting to membrane | −2.56 | 0.000 | 0.000 | −1.81 | 0.000 | 0.196 |
| Influenza viral RNA transcription and replication | −2.53 | 0.000 | 0.000 | −1.64 | 0.004 | 0.247 |
| 3 UTR mediated translational regulation | −2.51 | 0.000 | 0.000 | −1.62 | 0.009 | 0.256 |
| Peptide chain elongation | −2.46 | 0.000 | 0.000 | −1.51 | 0.031 | 0.292 |
| Influenza life cycle | −2.40 | 0.000 | 0.000 | −1.64 | 0.009 | 0.247 |
| Nonsense mediated decay enhanced by the exon junction complex | −2.33 | 0.000 | 0.000 | −1.47 | 0.034 | 0.301 |
| Metabolism of proteins | −2.31 | 0.000 | 0.000 | −1.81 | 0.000 | 0.199 |
| Activation of the mRNA upon binding of the cap binding complex and EIFS and subsequent binding to 43S | −2.29 | 0.000 | 0.001 | −1.52 | 0.035 | 0.290 |
| Formation of the ternary complex and subsequently the 43S complex | −2.25 | 0.000 | 0.001 | −1.54 | 0.036 | 0.279 |
| Metabolism of mRNA | −2.20 | 0.000 | 0.004 | −1.46 | 0.016 | 0.307 |
| Metabolism of RNA | −2.18 | 0.000 | 0.004 | −1.57 | 0.003 | 0.271 |
| mRNA splicing minor pathway | −2.11 | 0.000 | 0.014 | −1.74 | 0.015 | 0.224 |
| Protein folding | −1.95 | 0.000 | 0.072 | −1.77 | 0.009 | 0.213 |
| mRNA splicing | −1.93 | 0.000 | 0.081 | −1.75 | 0.003 | 0.219 |
| Activation of chaperone genes by XBP1S | −1.89 | 0.006 | 0.100 | −2.03 | 0.000 | 0.094 |
NES, normalized enrichment score; NOM p, nominal p-value; FDR q, false discovery q-value. All numbers for gene sets enriched with nominal p ≤ 0.05 and FDR q ≤ 0.2 are shown in bold.