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. 2018 Sep 20;9:2170. doi: 10.3389/fimmu.2018.02170

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Copyright © 2018 Schoenhals, Cushman, Barsoumian, Li, Cadena, Niknam, Younes, Caetano, Cortez and Welsh.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Long term effector memory is established in 129Sv/Ev mice challenged with 344SQ_R tumors and treated with XRT + anti-PD1 + anti-GITR. Mice previously treated with triple therapy who had total resolution of tumors (n = 4) were rechallenged with 1 × 10⁶ 344SQR cells at the abscopal site and compared with control mice (n = 3), prevously treated with Ctrl IgG. (A) Survival of rechallenged mice vs. controls. CD4 and CD8 T-cells from (B) spleen (C) secondary tumor draining lymph node and (D) peripheral blood are analyzed 90 days after the secondary abscopal tumor clearance. (E, F) Cells are gated on CD3⁺ then on CD44^hi and CD62L^low population. *P ≤ 0.05; **P ≤ 0.01 in Student t-tests.