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. 2018 Sep 20;9:2170. doi: 10.3389/fimmu.2018.02170

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Copyright © 2018 Schoenhals, Cushman, Barsoumian, Li, Cadena, Niknam, Younes, Caetano, Cortez and Welsh.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Anti-GITR therapy reduces regulatory T cells and increases the CD4 / Treg ratio at the tumor site but not in the spleen. Immune cells isolated from murine tumors were phenotyped 22 days after tumor inocluation. (A) Tumor-infiltrating leukocytes (TIL) and (B) splenocytes were isolated and evaluated for CD4, CD8, and Foxp3 expression. Foxp3+ values are shown after gating from within CD4+ cells. The CD4+ Foxp3– values were divided by the CD4+ Foxp3+ values to display the ratio. *P ≤ 0.05 in Student t-tests.