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. 2018 Sep 20;9:2170. doi: 10.3389/fimmu.2018.02170

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Copyright © 2018 Schoenhals, Cushman, Barsoumian, Li, Cadena, Niknam, Younes, Caetano, Cortez and Welsh.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Anti-GITR IgG2a depletes Tregs at the tumor site and promotes abscopal effects when combined with radiation and anti-PD1, while anti-GITR IgG1 expands Tregs and does not promote abscopal effects. (A) Flow cytometry percentages of CD4+ Foxp3+ T cells in gated lymphocytes isolated from tumors and spleens, 6 days post XRT. (n = 6) (B) Primary and (C) secondary tumors were inoculated and XRT was delivered 10 days post tumor inoculation (n = 6). (D) Survival was monitored out to day 63 (n = 6). *P ≤ 0.05 in Student t-tests.