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. 2018 Sep 20;12:637. doi: 10.3389/fnins.2018.00637

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Copyright © 2018 Rafa-Zabłocka, Kreiner, Bagińska and Nalepa.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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mRNA expression of genes encoding for Creb1, neurotrophins (Bdnf, Ngf, and Ntf3) and their receptors (Ntrk2, Ntrk3) in the hippocampus of saline- and fluoxetine-treated wild-type, Creb1^TPH2CreERT2, and Creb1^TPH2CreERT2Crem–/– mice. Neither genotype nor fluoxetine influenced the mRNA expression of Creb1, Bdnf, Ngf, Ntf3, Ntrk2, and Ntrk3. Bars represent fold changes in the mRNA expression of Creb1, Bdnf, Ngf, Ntf3, Ntrk2, and Ntrk3 vs. that in wild-type non-treated animals (dot line) in the hippocampus of (A) wild-type fluoxetine-treated, (B,C) Creb1^TPH2CreERT2 saline- and fluoxetine-treated, and (D,E) Creb1^TPH2CreERTCrem–/– saline- and fluoxetine-treated mice. All graphs show data from males (left) and females (right). W/t, wild-type; FLX, fluoxetine. Data are presented as the mean ± SEM.