Table 1.
Expression of mRNA encoding for BDNF and BDNF protein in w/t, Creb1TPH2CreERT2 and Creb1TPH2CreERT2Crem−/− mice after fluoxetine treatment.
| Hippocampus |
Prefrontal cortex |
|||||
|---|---|---|---|---|---|---|
| Sex | Treatment | Genotype | BDNF mRNA | BDNF protein | BDNF mRNA | BDNF protein |
| MALE | +SAL | Creb1TPH2CreERT2 | – | – | – | – |
| Creb1TPH2CreERT2Crem−/− | – | – | – | – | ||
| +FLX | Wild type | – | ↑ | – | – | |
| Creb1TPH2CreERT2 | – | – | – | – | ||
| Creb1TPH2CreERT2Crem−/− | – | ↑ns | – | ↑ns | ||
| FEMALE | +SAL | Creb1TPH2CreERT2 | – | – | – | – |
| Creb1TPH2CreERT2Crem−/− | – | – | – | – | ||
| +FLX | Wild type | – | ↑ | – | ↑ | |
| Creb1TPH2CreERT2 | – | – | – | – | ||
| Creb1TPH2CreERT2Crem−/− | – | ↑ns | – | ↑ns | ||
Arrows represent significant changes in BDNF expression vs. saline treated w/t mice. n/s, not significant; SAL, saline; FLX, fluoxetine.