TABLE 4.
Differential gene expression between productive HPV16 infection and cancers
| Gene | Fold change in expression in productive HPV infection | Cancers in which gene expression increases and/or promotes disease progression [reference(s)]a |
|---|---|---|
| SERPINB4 | −48.0 | HNSCC (67), cervical (69, 71), esophageal (70), lung (99), liver (86), breast (85) |
| KLK5 | −3.2 | Bladder (100), ovarian (101), lung (102), breast (103), OSCC (75) |
| KLK6 | −22.1 | Bladder (100), ovarian (101), colorectal (104), HNSCC (105), pancreatic (106) |
| KLK8 | −25.8 | Bladder (100), ovarian (101), salivary gland (107), cervical (76), OSCC (75), colorectal (106) |
| KLK10 | −7.6 | Ovarian (101), OSCC (75), pancreatic (106), colorectal (106) |
| KLK13 | −21.5 | Lung (108), ovarian (109) |
| MMP9 | −17.1 | Cervical (40), breast (110), HNSCC (111), prostate (112) |
| MMP10 | −8.0 | OSCC (113), HNSCC (114), esophageal (115) |
| LCN2 | −9.1 | Breast (42, 43), esophageal (44), pancreatic (45), ovarian (46), colorectal (47), thyroid (48) |
| CTSD | −1.5 | Breast (116), ovarian (117) |
| CTSV | −2.8 | Breast (118), colorectal (118) |
a
OSCC, oral squamous cell carcinoma; HNSCC, head and neck squamous cell carcinoma.