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SH3cI and CIN85 ligands of pUL135 are conserved between human and chimpanzee CMV strains. A schematic of HCMV pUL135 and ChCMV pUL135 is shown to scale. M1, M21, and M97 indicate the methionine codons where translation of UL135 initiates for HCMV pUL135. SH3cI ligands are shown in light gray; CIN85 ligands are shown in dark gray. Amino acid sequences are shown for ChCMV, and underlined residues indicate anchor residues essential for binding to Abi-1 or CIN85. TMD, transmembrane domains.
