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Examples of the wobble uridine modification at C5. Chemical structures of modified uridine at the wobble position (U34) is shown with (A) alkylation or (B) O-alkylation at C5 of pyrimidine. 5-methyluridine (m5U), 5-taurinomethyluridine (τm5U), 5-carboxymethylaminomethyluridine (cmnm5U), 5-hydroxyuridine (ho5U), 5-methoxyuridine (mo5U), 5-carboxymethyluridine (cmo5U), 5-carboxymethoxyuridine (mcmo5U).
