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DmHen1 shows no preference for natural cofactor or its synthetic analogue. 2 μM of DmHen1 was used to modify 0.2 μM of siR23 in the presence of 100 μM of cofactor in total, were AdoMet 1 and Ado-6-azide 3 were mixed in 10:0, 9:1, 8:2, 7:3, 6:4, 5:5, 4:6, 3:7, 2:8, 1:9 and 0:10 ratios, respectively.
