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. 2018 Jun 28;46(17):9119–9133. doi: 10.1093/nar/gky565

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© The Author(s) 2018. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 7. — RNA regulatory element organization influences the outcome of MBNL-determined AS profile. (A) Upon MBNL binding to distinctly arranged or structured RNA motifs, changes in availability or conformation of splice-activation elements of the protein may occur and lead to alterations in the strength of the MBNL interaction with other splicing factors including U2 auxiliary factor 65 kDa subunit (U2AF65), resulting in weakened or enhanced alternative CE inclusion (depicted by the size of green arrows). (B) A model in which MBNL1 and MBNL3 compete at a dose- and RNA substrate-dependent manner during muscle development and regeneration as well as in pathological conditions (DM) modulating the AS profile; more explanation in the text. To simplify, MBNL splicing isoforms and MBNL2 paralog were omitted in the scheme.