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. 2018 Jun 28;46(17):8788–8802. doi: 10.1093/nar/gky580

Figure 4.

Figure 4.

Differential KAP1-mediated maintenance of H3K9me3 and H4K20me3. (A) KAP1, H3K9me3 and H4K20me3 ChIP-Seq peaks in WT and Kap1 KO MEFs, pointing on top to regions (1, 2 and 3 asterisk) with differential patterns. (B–D) Heatmaps representing the raw data –/+10 kb around the middle of histone mark peaks in WT and Kap1 KO MEFs. H3K9me3/H4K20me3-positive regions were defined with a stringent P-value (10e–8), and specific loci as positive according to this criterion in one dataset and negative even with low stringency P-value in the other data set (<10e–8 versus >10e–3).