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. 2018 Jun 28;46(17):8788–8802. doi: 10.1093/nar/gky580

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© The Author(s) 2018. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 7. — A model for heterochromatin maintenance across cell division. During S phase, the complex SETDB1-KAP1-CAF1 induces the mono-methylation of lysine 9 on histone H3 (1), which is incorporated into nucleosomes via CAF1 (2). During late S phase (3), an unknown kinase phosphorylates KAP1 on serine 473, which promotes interaction with PCNA and other replication factors. At the replication fork, KAP1 recruits Suv39h1, which mediates the formation of H3K9me3 (4). During Interphase, nucleosomal H3K9me3 is recognized by HP1 (5), which in turn tethers Suv420h1, responsible for the tri-methylation of H4K20 (6), whereas an unknown KMT mediates the formation of H3K64me3 in an H3K9me3-dependant manner (7).