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EZH2 inhibitor suppresses HCC growth through epigenetic rectification. (A) The Huh7 cell-derived xenograft tumors were dissected from nude mice treated with or without selective inhibitor of AKT (AKTi) and/or EZH2 (EZH2i), of which volumes were quantified (n = 4) and shown in (B). (C) The expression of transcription factors and cellular regulators in the vehicle-treated and EZH2i-treated tumors was measured by qRT-PCR analysis. *P < 0.05; **P < 0.01; ***P < 0.001.
