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. 2018 Sep 26;3(5):e00408-18. doi: 10.1128/mSphere.00408-18

TABLE 3.

Susceptibility profiles of E. coli TOP10 pTRC-blaKPC-2 constructs

Antimicrobial agenta MIC (µg/ml) for E. coli TOP10
No
plasmid		 blaKPC-2 WT blaKPC-2-D179Y blaKPC-2-D176Y blaKPC-2-R164S +
P174L		 blaKPC-2-R164S blaKPC-2-P174L
Ceftazidime ≤0.25 16 128 64 128 64 32
Ceftazidime-avibactam ≤0.25 ≤0.25 8 8 8 2 2
Ceftriaxone ≤0.03 64 8 4 8 16 16
Ceftriaxone-avibactam ≤0.03 ≤0.03 0.12 0.25 0.25 0.12 0.12
Cefepime ≤0.03 8 1 1 1 2 2
Cefepime-avibactam ≤0.03 ≤0.03 0.06 0.06 0.12 0.06 0.06
Piperacillin 8 >128 >128 128 128 >128 >128
Piperacillin-avibactam 4 8 16 8 16 16 16
Imipenem 0.25 4 0.25 0.5 0.25 1 2
Imipenem-avibactam 0.12 0.12 0.12 0.12 0.12 0.12 0.25
Meropenem ≤0.015 1 0.03 0.03 0.06 0.25 0.25
Meropenem-avibactam ≤0.015 ≤0.015 ≤0.015 ≤0.015 ≤0.015 ≤0.015 ≤0.015
Aztreonam 0.12 >16 2 8 2 >16 >16
Aztreonam-avibactam 0.12 0.25 0.25 0.25 0.25 0.12 0.12
a

Avibactam was tested at a fixed concentration of 4 µg/ml in all cases.