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. 2018 Jun 18;27(7):1111–1125. doi: 10.1177/0963689718773333

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© The Author(s) 2018

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Fig. 1. — Schedule and design of the study. At 1 day before surgery, three sheep were randomly selected to perform baseline MRI. In total, 34 sheep were performed ACLT+MM in which 30 sheep were divided into saline, HA, low ASC+HA, high ASC+HA, and SVF+HA groups, and 7 weeks later another operation took place to isolate adipose tissue manufacturing SVF and ASCs. At 12 and 15 weeks after surgery, each group was treated by different interventions. 30 sheep were sacrificed at week 27 after surgery. The remaining four sheep were used in the tracking study with SPIO-labeled ASC injection at week 12 and sacrificed at week 14 and week 30, respectively.

ACLT: anterior cruciate ligament transection; ASC: adipose mesenchymal stem cell; HA: hyaluronic acid; MM: medial meniscectomy; MRI: magnetic resonance imaging; SPIO: superparamagnetic iron oxide particle; SVF: stromal vascular fraction.