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. 2018 Jun 18;27(7):1111–1125. doi: 10.1177/0963689718773333

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© The Author(s) 2018

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Fig. 2. — After OA model was successfully induced, MR imaging indicated the efficacy of autologous low-dose ASC+HA treatment. (A) MRI was performed at pre-operation (pre-op), 12 weeks post-operation (12 w), and 27 weeks post-operation in different treatments (non-injured, saline, HA, low ASC+HA, high ASC+HA, and SVF+HA). In the pre-op and non-injured groups, T2 sequence of 3.0 T MRI showed smooth cartilage layer and clear synovium lining; however, at 12 weeks post-surgery and in the saline and HA groups, the T2 sequence of the MRI exhibited damaged cartilage and hydropic synovium. ASC+HA and SVF+HA treatments improved cartilage injury, bone marrow lesions of subchondral bone, synovial hydropic swelling. (B) MOCART scores in low-dose ASC+HA treatment were significantly higher than those in the saline and HA groups. The P-values were obtained using a Kruskal–Wallis test and Dunn’s post-test (*P<0.05). Data were collected from three repetitions (n=3).

ASC: adipose mesenchymal stem cell; HA: hyaluronic acid; MOCART: magnetic resonance observation of cartilage repair tissue; MRI: magnetic resonance imaging; OA: osteoarthritis; SVF: stromal vascular fraction.