Figure 1.

Schematic of the experimental protocol. At baseline, pigs were fed either a MetS (n = 21) or Lean diet (n = 7). Six weeks later, RVD was induced in 14 MetS pigs, whereas 7 Lean and 7 MetS pigs underwent a sham procedure. Six weeks after induction of RVD, MetS+RVD pigs received a single intra-renal infusion of either autologous MSC-derived EVs or vehicle (n = 7 each). Other MetS and Lean pigs underwent sham procedures (n = 7 each). Four weeks later, pigs were studied in-vivo and ex-vivo.