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. 2018 Aug 21;8(2):11–23. doi: 10.1159/000490499

Table 4.

Adjusted modelsa showing the association between OBS and biomarkers of inflammationb, stratified by CKDc, in the REGARDS cohort weighted random sample (n = 682)

IL-6 IL-8 IL-10 Fibrinogen CRP WBC count Cys C
Interaction
 p valued 0.03 0.3 0.03 0.09 0.2 0.5 <0.001
CKD (n = 153)
OBSe −0.1 14.7 −1.3 1.7 −11.4 10.7 1.7
 95% CI −13.5, 15.4 0.3, 31.1 −26.7, 32.9 −3.7, 7.4 −32.4, 16.2 −0.6, 23.3 −6.6, 10.7
p value 0.9 0.04 0.9 0.5 0.4 0.06 0.7
OBS
 Interval 1f - - - - - - -
 Interval 2f −7.0 −2.2 −32.9 −13.1 −35.8 −7.6 −36.1*
  95% CI −49.7, 71.9 −43.7, 69.7 −79.5, 120.2 −30.4, 8.4 −78.7, 93.7 −36.0, 33.3 −54.4, −10.4
 Interval 3f −16.6 4.8 40.8 −13.3 −56.2 −10.9 −37.5*
  95% CI −54.1, 51.5 −39.3, 80.8 −56.5, 356.1 −30.3, 7.7 −85.3, 30.5 −37.5, 27.0 −55.3, −12.7
 Interval 4f −22.3 16.9 −6.8 −13.6 −54.6 10.8 −32.1*
  95% CI −57.6, 42.3 −32.6, 102.9 −71.6, 205.7 −30.8, 7.7 −84.9, 36.9 −23.8, 61.2 −51.6, −4.8
 Interval 5f 31.9 59.0 −16.3 2.5 −35.0 4.0 −26.9
  95% CI −41.7, 198.6 −24.1, 233.0 −83.0, 311.9 −23.9, 38.0 −85.2, 185.7 −36.9, 71.4 −53.5, 15.0
p for trend 0.5 0.05 0.9 0.9 0.3 0.06 0.6
No CKD (n = 529)
OBSe −10.7 −3.9 7.5 −1.9 −19.6 −0.3 −1.1
  95% CI −16.3, −4.7 −10.8, 3.6 −3.7, 19.9 −4.9, 1.0 −30.1, −7.5 −4.3, 4.0 −3.1, 1.0
p value 0.001 0.3 0.2 0.2 0.002 0.9 0.3
OBS
 Interval 1f - - - - - - -
 Interval 2f 4.5 0.0 36.7 6.0 −37.4 −9.0 6.2
  95% CI −19.3, 35.4 −25.8, 34.7 −11.5, 111.1 −6.1, 19.6 −64.2, 9.5 −22.2, 6.4 −2.3, 15.5
 Interval 3f −4.9 −0.4 48.1 0.7 −45.0* −8.6 4.6
  95% CI −26.5, 23.0 −26.0, 34.1 −3.8, 128.0 −10.7, 13.5 −68.4, −4.1 −21.9, 7.0 −3.7, 13.6
 Interval 4f −10.9 0.8 43.8 0.2 −50.4* −5.0 4.6
  95% CI −31.4, 15.9 −25.6, 36.4 −7.4, 123.3 −11.4, 13.4 −71.9, −12.6 −19.1, 11.5 −5.6, 11.9
 Interval 5f −21.0 −16.8 53.5 2.6 −49.7* −16.2 0.9
  95% CI −42.4, 8.3 −42.1, 19.4 −9.3, 159.6 −11.3, 18.8 −74.4, −1.3 −31.0, 1.7 −8.8, 11.5
p trend 0.004 0.5 0.3 0.3 0.03 0.8 0.2

OBS, oxidative balance score; IL, interleukin; CRP, C-reactive protein; WBC, white blood cell; Cys C, cystatin C; CKD, chronic kidney disease; CI, confidence interval.

a

Adjusted for age, sex, race, region, smoking status, BMI, protein, calories, NSAID, aspirin, and statin use.

b

Natural log-transformed.

c

CKD was defined as eGFR<60 mL/min/1.73m2 or albuminuria ≥30 mg/g.

d

p value for interaction based on continuous OBS.

e

Estimates represent percent difference per 5-unit change in OBS.

f

Interval 1, OBS 0–5; interval 2, OBS 6–9; interval 3, OBS 10–13; interval 4, OBS 14–17; interval 5, OBS 18–22.

*

p < 0.05 for interval.