Table 1.
Summary of INFERNO region prioritizations for schizophrenia. Strong ABF refers to signals where one variant had an ABF of 0.50 or higher for a co-localized eQTL signal
Prioritized variant | Prioritization approach | Tissue and target gene |
---|---|---|
rs4766428 (12q24.11) | Strong ABF + TFBS + concordant enhancer | 12 signals including C12orf76 and VPS29 in brain and TCTN1 in nerve |
rs12826178 (12q13.3) | Strong ABF + concordant enhancer | TSPAN31 in blood |
rs56205728 (15q15.1) | Strong ABF + concordant enhancer | BUB1B in brain, PAK6 and PLCB2 in skeletal muscle |
rs4702 (15q26.1) | Strong ABF + concordant enhancer | FES in subcutaneous adipose and pancreas, SLCO3A1 in transformed fibroblasts, and FURIN in esophagus mucosa |
rs6002655 (22q13.2) | Strong ABF + concordant enhancer | NDUFAF6, RANGAP1, RP4-756G23.5 in blood |