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. 2018 Aug 27;46(17):8665–8678. doi: 10.1093/nar/gky768

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© The Author(s) 2018. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — Single amino acid substitutions in H2A affect the nucleosome surface and structure. (A) Threonine 16 of H2A is exposed on the surface of the nucleosome. A space-filling model of the canonical nucleosome was generated in PyMOL using the spheres feature. Threonine 16 on H2A is highlighted in purple. (B) Zoomed-in view of the region highlighted with a gray box in (A). (C) Zoomed-in molecular surface representations of nucleosomes containing threonine (C) or serine (D) at residue 16 of H2A (highlighted in purple) were generated in pymol using the mutagenesis and surface features. (E) Alanine 40 of H2A, highlighted in royal blue, interacts with isoleucine of H2B via hydrophobic side chain interactions. For all images, H3 is light blue, H4 is green, H2A is orange, and H2B is red. The crystal structure of the canonical nucleosome (PDB: 1AOI) was used for all images.