Table 4.

Histone H4 isoforms with the corresponding protein name, molecular weight and relation to carcinogenesis

Gene name(s)	Protein name(s)	Molecular weight	Significance	Reference(s)
HIST1H4G	H4 1G* (needs validation)	10 920	Downregulated in endometrioid carcinoma; upregulated by HuR silencing in tumorigenic thyroid cell line; upregulated in T-cell prolymphocytic leukemia	(116,122,145)
HIST1H4I	H4 1I	11 250	Expressed specifically in malignant pool in ovarian cancer tumor fluid; deleted in colon cancer, downregulated in chronic myelogenous leukemia stem cells; mutated in acral melanoma; hypermethylated in parathyroid adenomas versus normal parathyroid glands	(102,105,131, 146–148)
HIST1H4A/B/C/D/E/F/H/J/K/L	H4	11 278
HIST2H4
HIST4H4