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. 2018 Aug 10;15(12):1341–1348. doi: 10.7150/ijms.27543

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Effect of thrombopoietin in ischemia-reperfusion rats' brains. (A) TTC staining of brain slices after ischemia- reperfusion. Uniformly red region in Sham operation group (a) vs. white infarct lesion in IR group (b) and TPO intervention group(c). (B) Compared with sham operation group, the neurological deficit scores were significantly increased in IR and TPO intervention group, and TPO intervention decreased neurological deficit at 24h after MCAO. (C) The brain water content of ischemic hemispheres was significantly increased after MCAO, and TPO intervention reduced ischemia-induced increase of brain water content, whereas no difference was found in contralateral hemispheres. (D) The Evan's blue extravasation of ischemic hemispheres is significantly higher than that of sham group and contralateral hemispheres in IR and TPO intervention group, and TPO intervention reduced Evan's blue content significantly compared with the IR group. (^★Compared with the sham operation group, P<0.05; ^▲Compared with the IR group, P<0.05; ^■Compared with the contralateral brain, P<0.05)