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. 2018 Sep 26;38(39):8407–8420. doi: 10.1523/JNEUROSCI.3458-17.2018

Figure 2.

Figure 2.

Allele-dependent relationships between circulating FKBP5 mRNA expression levels and circulating cortisol levels or between FKBP5 mRNA and circulating NR3C1 mRNA expression levels in the early aftermath of MVC. A, Correlation between plasma cortisol levels and circulating FKBP5 mRNA expression levels in individuals with two copies of the rs3800373 protective/major allele (n = 27, r = 0.253, p = 0.202). B, Correlation between plasma cortisol levels and circulating FKBP5 mRNA expression levels in individuals with at least one copy of the risk/minor allele (n = 51, r = 0.512, p = 1.2 × 10−4). C, Correlation between circulating NR3C1 and FKBP5 mRNA expression levels in individuals with two copies of the rs3800373 protective allele (n = 28, r = 0.091, p = 0.645). D, Correlation between circulating NR3C1 and FKBP5 mRNA expression levels in individuals with at least one copy of the rs3800373 risk allele (n = 66, r = 0.560, p = 8.3 × 10−7). Pearson correlation coefficients (r) and p values were calculated using bivariate analyses.