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A schematic model illustrating the functional roles of DDX49. DDX49 is involved in the maintenance of the pre-ribosomal 47S RNA levels by enhancing its transcription and stability and is required for the efficient export of mRNAs and global translational regulation. Physiologically DDX49 influences cell growth and proliferation. However, in pathological conditions, especially cancers, elevated levels of DDX49 promote the oncogenic transformation of the cells.
