Figure 3.

Decreased correlation between different cell types with increasing resolution. (A) Map resolution evaluation using the proportion of bins with interaction counts > 1,000. At 15-kb resolution, more than 80% of bins have at least 1,000 contacts. At 40-kb resolution, over 90% of bins have at least 1,000 contacts. (B) Pearson's correlation analysis at four resolutions from low to high (1 Mb, 500 kb, 100 kb, and 40 kb). In each sample pair, Pearson's correlation analysis was performed in each chromosomal cis interaction matrices, then a mean Pearson's r of 19 euchromosomes was obtained as shown.