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. 2018 Sep 7;14(11):1571–1585. doi: 10.7150/ijbs.25328

Figure 5.

Figure 5

Compartment A/B changes of adipogenesis and myogenesis marker genes are coordinated with gene expression changes. Compartment strength in each chromosome of four cell types. The compartment strength is divergent during cell differentiation and between cell types (P = 3.61×10-3 in 3T3-L1 vs. 3T3-L1-D, P = 2.00×10-8 in 3T3-L1 vs. C2C12, P = 2.56×10-3 in 3T3-L1 vs. C2C12, P = 1.00×10-3 in 3T3-L1-D vs. C2C12-D, Student's t-test). Percentage of the genome that changes A/B compartment upon adipogenic and myogenic differentiation, as well as between proliferating and differentiated 3T3-L1 and C2C12. (C, D) Significantly highly expressed adipogenesis (C) and myogenesis (D) marker genes have more positive PC1 values after differentiation. These marker genes are well known and widely reported. Negative PC1 value represents compartment B, positive PC1 value represents compartment A.