Figure 7.

Differential chromatin interactions contribute to differential gene expression. Histogram showing the proportion of DCIs (binomial P < 0.001) in the high-confidence interactions (binomial Benjamini-corrected FDR < 0.01). Pie chart showing the proportion of promoter interactions among the DCIs. The fraction of putative promoter-enhancer interactions and non-promoter-enhancer interactions in DCIs. The area of the pie chart represents the number of DCIs between each sample pair. The cyan region indicates the number of putative promoter-enhancer interactions, and the gray region indicates the number of non-promoter-enhancer interactions. Putative promoter-enhancer interactions were significantly enriched in DCIs than in the genome background (randomly selected). The FDR is based on the χ² test. Genes differentially expressed during cell differentiation and between cell types are significantly enriched in these putative promoter interactions, excluding between 3T3-L1 and C2C12. χ² test, (***) FDR < 0.001, (**) FDR < 0.01, (*) FDR < 0.05, (ns.) FDR > 0.05. Violin plot showing the difference of gene expression in these DCIs. Student's t-test, P < 0.05.