Fig 1.

Liver steatosis and injury were attenuated by polydatin in mice fed with MCD diet. Mice were fed with MCD diet or control diet for 4 weeks. Mice fed with MCD diet were intraperitoneal injected with 5 mg/kg polydatin daily in the period of experiment. (A-B) Representative histology of HE and Oil red O staining. (C) Histological analysis of steatosis, ballooning, inflammation and overall NAFLD activity scores in MCD-fed and polydatin-treated mice. Mean SE of results from controls (n=5), MCD diet-fed group (n=7) and PD treatment group (n=9); (D) Serum levels of ALT, AST and T. (E) The mRNA levels of FAS, SREBP-1c were measured by q-PCR. (F) The curve of body weight of mice in the period of diet feeding. Mean SE of results from controls (n=5), MCD diet-fed group (n=7) and PD treatment group (n=9). ^## p < 0.01, ^###p < 0.001, ^####p < 0.0001 vs control mice; ^*p < 0.05, ^**p < 0.01, ^****p < 0.0001 vs mice induced by MCD.